I been thinking of using AviScreen Portable (http//
It depends on how "portable" that build of AVIScreen is. A simple way to check (most) changes would be to test it with RegShot available free from Sourceforge on a clean system (virtual machine).
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If your going to start using portable software then its worth checking out sites such as The Portable Freeware Collection, PortableApps and LiberKey. They all have lots of free ready to use portable applications and very active communities and forums that will help you test and build software to run from usb/cd/dvd.
You will have to accept that connecting any USB device to a computer will have some affect on a system. Being aware of those changes and thoroughly testing first is very important.